Conductive Covalent Organic Frameworks as Chemiresistive Sensor Arrays for the Detection and Differentiation of Gasotransmitters

Link: https://pubs.acs.org/doi/full/10.1021/jacs.5c11454

Abstract: This paper describes a chemiresistive sensor array using four structurally analogous, but chemically distinct, conductive covalent organic frameworks (COFs) (M-COF-DC-8, M = Fe, Co, Ni, and Cu) capable of detecting and differentiating four important gaseous analytes: nitric oxide (NO), carbon monoxide (CO), hydrogen sulfide (H2S), and ammonia (NH3). The COFs were synthesized from the condensation of 2,3,9,10,16,17,23,24-octaamino-metallophthalocyanine precursors with pyrenetetraone linkers resulting in chemically robust and electrically conductive materials. Chemiresistive sensing experiments, together with machine learning to parse the response pattern of the sensor array, show that the M-COF-DC-8 (M = Fe, Co, Ni, Cu) materials can detect and differentiate this suite of oxidizing and reducing gases at parts-per-million concentrations, with theoretical limits of detection (LOD) in the parts-per-billion range in dry N2. Importantly, the COF array containing M-COF-DC-8 (M = Co, Ni, Cu) retains its ability to detect and differentiate these analytes in air and humidity under low power consumption. Spectroscopic investigations reveal that the synthetic control over the identity of the metallophthalocyanine core efficiently tunes material–analyte interactions and, therefore, emergent device performance. The use of highly tunable COFs as the active material in sensor arrays enables low-power, sensitive, and real-time gas detection with future applications in healthcare and personal protection.

Recommended citation: Conductive Covalent Organic Frameworks as Chemiresistive Sensor Arrays for the Detection and Differentiation of Gasotransmitters Georganna Benedetto, Robert M. Stolz, Zheng Meng, Joseph Y. M. Chan, Elissa O. Shehayeb, Colin T. Morrell, Gbenga Fabusola, Nikolaus Elsaesser, Cory M. Simon, and Katherine A. Mirica Journal of the American Chemical Society 2025 147 (47), 43438-43452 DOI: 10.1021/jacs.5c11454
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